Polymyxin B to polypeptide antibiotic resistant gram-negative bacillus and can change the membrane structure make the leakage of smaller molecules and inhibit the growth of gram-negative bacteria. In e. coli bactericidal effect. To bacterial lipopolysaccharide lipid part A. In the cortical cell membrane induced hole. Role model: combining and interfere with the permeability of cytoplasm membrane. Antibacterial spectrum: gram negative bacteria.
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